Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches

Psoriasis: from pathogenesis to novel therapeutic approaches.

Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but a wealth of studies indicate that the disease results from a complex and dynamic interplay between genetic and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines pro...

Alzheimer’s disease: from pathogenesis to novel therapeutic approaches

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, with a prevalence of 5% after 65 years of age, increasing to approximately 30% in people aged 85 years or older. It is characterized clinically by progressive cognitive impairment, including impaired judgement, decision-making and orientation, often accompanied, in later stages, by psychobehavioral disturbances and la...

Therapeutic approaches to vascular protection in ischemic stroke.

Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to br...

microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement disorder and the second most common neurodegenerative disease overall. PD is characterized by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc) within the midbrain, accumulation of alpha-synuclein (α-SYN) in Lewy bodies and neurites and excessive neuroinflammati...

Transplant Vascular Sclerosis: from Pathogenesis to Prevention